Quick Overview:
Angiplat 2.5 contains Nitroglycerin (Glyceryl Trinitrate), a potent organic nitrate vasodilator. It acts primarily as a prodrug that undergoes hepatic and vascular metabolism to release active nitric oxide ($NO$). Nitric oxide stimulates the enzyme guanylyl cyclase, leading to an increase in intracellular cyclic guanosine monophosphate ($cGMP$). This downstream signaling cascade dephosphorylates myosin light chains, causing deep relaxation of vascular smooth muscle tissue.
No description available.
Uses / Indications
Prophylaxis of Angina Pectoris: Prescribed for the long-term prevention and reduction in frequency of chronic, stable chest pain episodes caused by coronary artery disease.
Management of Chronic Heart Failure: Used as an adjunctive treatment to lower cardiac filling pressures and reduce systemic vascular strain.
Key Benefits
Sustained Anti-Anginal Protection: The timed-release design provides stable medication levels in the blood, helping prevent sudden, unexpected chest pain throughout the day.
Optimized Exercise Capacity: By lowering the heart's oxygen demands, it allows individuals to stay active and walk further before experiencing chest tightness.
Targeted Preload Reduction: Smoothly reduces physical strain and pressure load inside the heart chambers without abruptly altering resting heart rates.
As Directed by a Physician: The standard oral preventative dose is typically 1 capsule taken 2 to 3 times daily, tailored to the patient's specific cardiovascular tolerance.
Nitrate Headache: A very common, throbbing headache caused by meningeal arterial dilation. This side effect typically becomes less severe or disappears after a few days of continuous use and can be managed with standard analgesics.
Dizziness, lightheadedness, or postural instability
Orthostatic hypotension (feeling faint or dizzy when standing up quickly)
Cutaneous flushing (warmth or redness in the face and neck)
Weakness or mild palpitations
- Store in a cool dry place
- Keep away from direct sunlight
- Keep out of reach of children
- Read the label carefully before use
