Quick Overview:
Angispan-TR contains Nitroglycerin, an organic nitrate prodrug. Once absorbed, it undergoes metabolic conversion in vascular smooth muscle cells to generate active nitric oxide ($NO$). This nitric oxide stimulates the enzyme guanylyl cyclase, increasing intracellular levels of cyclic guanosine monophosphate ($cGMP$). Elevated $cGMP$ dephosphorylates myosin light chains, prompting direct relaxation of vascular smooth muscle tissue.
No description available.
Uses / Indications
Prophylaxis of Angina Pectoris: Utilized for the long-term, routine prevention and reduction in frequency of chronic chest pain episodes caused by coronary artery disease.
Adjunctive Heart Failure Therapy: Sometimes used alongside other cardiovascular agents to help reduce standard filling pressures in chronic congestive heart failure.
Key Benefits
Around-the-Clock Angina Prevention: The timed-release micro-dialysis delivery system provides a steady distribution of nitroglycerin, cutting down unexpected daytime chest pain.
Increased Physical Freedom: Lowering the heart's work burden enables patients to walk longer distances or perform everyday activities with fewer restrictions.
Balanced Cardiac Offloading: Comfortably drops preload pressures on the heart chambers without demanding an abrupt increase in resting heart rate.
As Directed by a Physician: The dosage is highly individual and depends on clinical titration and patient tolerance.
Nitrate Headache: A throbbing headache caused by the widening of blood vessels in the brain. It is very common when starting treatment but typically fades within a few days and responds well to standard mild pain relievers.
Dizziness, lightheadedness, or feeling faint
Orthostatic hypotension (a drop in blood pressure when sitting up or standing quickly)
Flushing (warmth, redness, or tingling of the face and neck)
Mild physical weakness
- Store in a cool dry place
- Keep away from direct sunlight
- Keep out of reach of children
- Read the label carefully before use
