Quick Overview:
Amaryl M1 is a fixed-dose combination anti-diabetic medication. It combines two active mechanisms: Glimepiride (a Sulfonylurea insulin secretagogue that increases insulin production from the pancreas) and Metformin (a Biguanide that decreases glucose production in the liver, delays glucose absorption in the intestines, and improves insulin sensitivity). The Metformin component is in a prolonged-release (PR) formulation to provide gradual, steady release throughout the day.
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Uses / Indications
Indicated for the management and treatment of Type 2 Diabetes Mellitus in adults when blood sugar levels cannot be adequately controlled by a single medication, diet, and exercise alone.
Key Benefits
Provides dual-action glycemic control by simultaneously addressing insulin production and insulin resistance.
Effectively stabilizes both fasting and post-prandial (after-meal) blood glucose loads.
Dual-combination therapy helps significantly reduce overall HbA1c levels, mitigating long-term risk profiles for diabetic nephropathy, retinopathy, neuropathy, and chronic vascular complications.
Administration: The tablet must be swallowed whole with water, without chewing or crushing. It is usually prescribed to be taken once daily with or immediately after the first main meal of the day (breakfast).
Important: The precise dosage frequency and strategy must be closely regulated and monitored by your healthcare provider. Never adjust, increase, or discontinue your dosage schedule without a physical consultation.
Hypoglycemia (Low Blood Sugar): Due to the glimepiride component. Symptoms include sudden cold sweats, shaking, lightheadedness, blurred vision, anxiety, and fast pulse rate.
Gastrointestinal discomfort: Taste alterations, nausea, abdominal pain, diarrhea, or loss of appetite (often transient and manageable by taking it with food).
Rare/Severe side effects: Vitamin B12 deficiency over long-term usage, lactic acidosis (a medical emergency characterized by deep breathing, muscle pain, and severe fatigue), and allergic skin responses.
- Store in a cool dry place
- Keep away from direct sunlight
- Keep out of reach of children
- Read the label carefully before use
