Quick Overview:
Amtas AT is a synergistic, fixed-dose combination antihypertensive tablet combining a calcium channel blocker (CCB) and a beta-blocker.Amlodipine is a long-acting dihydropyridine CCB that selectively inhibits calcium ion influx across L-type calcium channels into vascular smooth muscles. This results in direct arterial smooth muscle relaxation and peripheral vasodilation, lowering systemic blood pressure.
Atenolol is a cardioselective beta-1 adrenergic receptor antagonist ($\beta_1$-blocker). It blocks the effects of epinephrine and norepinephrine on cardiac tissue, reducing resting and exercise heart rates, decreasing myocardial contractility, and lowering total cardiac output.
The combination provides a highly balanced therapeutic approach. Amlodipine handles peripheral resistance via vasodilation, while atenolol counteracts any potential reflex tachycardia (racing heart rate) that CCBs can sometimes prompt, leading to comprehensive 24-hour blood pressure management.
No description available.
Uses / Indications
Hypertension (High Blood Pressure): Used when single-agent therapies are insufficient to reach blood pressure targets.
Chronic Stable Angina: Managed effectively by lowering cardiac workload and improving myocardial oxygen delivery.
Key Benefits
Dual Action Synergistic Efficacy: Combines two distinct therapeutic mechanisms to achieve stronger blood pressure reduction with lower doses of each drug.
Heart Rate and Workload Stabilization: Atenolol keeps the heart rate steady and managed, preventing the palpitations sometimes caused by amlodipine alone.
Cardiovascular Protection: Minimizes long-term pressure-related strain on vital organs, protecting the heart and brain from strokes and cardiovascular events.
As Directed by a Physician: Typically administered as one tablet orally once per day.
Peripheral Edema: Swelling of the ankles or lower legs due to fluid shift from amlodipine.
Bradycardia (an abnormally slow heart rate from atenolol).
Dizziness, lightheadedness, or tiredness/fatigue.
Cold hands or feet (due to beta-blocker vasoconstriction in extremities).
Flushing (warmth or redness in the face or neck).
Mild nausea or digestive discomfort.
- Store in a cool dry place
- Keep away from direct sunlight
- Keep out of reach of children
- Read the label carefully before use
